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110: With an ovary removed, when should I think about increasing progesterone or estrogen?

Masterjohn Q&A Files Episode 110


Carrie: You may actually need more progesterone. Like I was saying in the very beginning of this, that progesterone actually turns into that neurosteroid allopregnanolone, which can cross the blood-brain barrier and bind itself to GABA and affect sleep. It's very calming, obviously relaxing. It's GABA.

Carrie: Obviously, there are other things that affect sleep too. If your norepinephrine is going up at night, if you got blood sugar issues, if your cortisol is going up at night -- and norepinephrine is a big trigger for hot flashes for women, especially night sweats. It's one of its symptoms. Women think it's hot flashes and night sweats from hormones and really it's from norepinephrine. Getting stress under control, winding down at night, those things, if you're on any kind of adrenal support, nourishing adrenal as opposed to stimulating adrenal can be really helpful also.

This Q&A can also be found as part of a much longer episode, here: 

Harnessing the Power of Nutrients
050: Ask Us Anything About Hormones with Dr. Carrie Jones | May 10, 2019
Watch now (125 min) | On May 10, members of the CMJ Masterpass joined me and Dr. Carrie Jones in a live Zoom meeting to ask us anything about hormones, and here’s the full recording! We talk about things like: What time of day is best to take T4 and/or T3? How to use pregnenolone to manage perimenopausal insomnia…
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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

PLEASE NOTE: As a result of the COVID-19 crisis and the time I am committing to staying on top of relevant research, as well as the high volume of questions I receive, it may take me extra time to respond to questions here. For an up-to-date list of where I respond to questions most quickly, please see the contact page on

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The Masterjohn Q&A Files
We use Zoom, a video chatting software, in webinar mode. You can ask your question anonymously in text, but you can also ask it publicly, and you can even get "on stage" and share your mic, web cam, or screen with everyone.
Chris Masterjohn, PhD