078: Is there a potential for adverse effects of 5-10 mg of folate for heterozygous MTHFR?
Masterjohn Q&A Files Episode 78
Is there a potential? Yeah. The tolerable upper intake level for folate was set at 1 milligram on the basis that there are rare hypersensitivity syndromes that have caused reactions to 1 milligram or higher. On the basis that in numerous case reports, supplementation of more folate than that has been the factor that appears to precipitate the neurological degeneration in B12 deficient patients. It seems like if you're B12-deficient and you add a megadose of folate, there might be something causal about adding the folate precipitating the B12 deficiency. That makes sense.
This Q&A can also be found as part of a much longer episode, here: https://themasterpass.chrismasterjohnphd.com/products/mastering-nutrition/categories/2811836/posts/9361470
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