078: Is there a potential for adverse effects of 5-10 mg of folate for heterozygous MTHFR?

Masterjohn Q&A Files Episode 78


Is there a potential? Yeah. The tolerable upper intake level for folate was set at 1 milligram on the basis that there are rare hypersensitivity syndromes that have caused reactions to 1 milligram or higher. On the basis that in numerous case reports, supplementation of more folate than that has been the factor that appears to precipitate the neurological degeneration in B12 deficient patients. It seems like if you're B12-deficient and you add a megadose of folate, there might be something causal about adding the folate precipitating the B12 deficiency. That makes sense.

This Q&A can also be found as part of a much longer episode, here: https://themasterpass.chrismasterjohnphd.com/products/mastering-nutrition/categories/2811836/posts/9361470

Listen to the Audio

I highly recommend watching the video above but you can also listen to the audio here:

Read the Transcript or Leave a Comment

Masterpass members have access to the transcript below.

Masterpass members can also read and leave comments below. Non-members can read and leave comments on the general podcast page.

Learn more about the Masterpass here.

This video is for paid subscribers