048: Pantothenic Acid, Part 1 (What It Is and Why We Need It)
Mastering Nutrition Episode 48
00:37 Cliff Notes
08:01 Symptoms of experimentally induced pantothenic acid deficiency
09:56 It is thought that pantothenic acid deficiency doesn’t occur naturally.
12:58 Experiments inducing pantothenic acid deficiency
20:05 Signs and symptoms of suboptimal pantothenic acid status
20:53 Is there pantothenic acid toxicity?
24:52 Hypothetical problems of taking high doses of pantothenic acid
25:53 What pantothenic acid is
29:27 Comparisons to niacin and riboflavin
31:13 Roles of coenzyme A
40:02 Roles of 4’-phosphopantetheine
42:11 Burning fat requires 20% more vitamin B5 than burning carbohydrate; and why in the context of severe deficiency of B5 or impairment in the metabolism of B5 a high-fat diet could have devastating consequences.
47:09 The importance of the ratio of acetyl-CoA to free CoA in regulating many metabolic pathways
55:02 There are metabolic disorders, such as fatty acid oxidation disorders, that compromise the pool of coenzyme A.
57:02 Synthesis of coenzyme A
01:00:47 How coenzyme A synthesis is regulated
01:05:38 Degradation of coenzyme A
01:09:44 The physiology of pantothenic acid absorption
01:19:29 A 2015 paper showed that 4’-phosphopantetheine can cross cell membranes via passive diffusion.
01:22:59 The physiology of pantothenic acid transport in the blood
01:26:11 Cellular uptake of pantothenic acid from the blood
01:27:20 Tissue distribution of pantothenic acid
01:30:00 There may be a particularly high need for pantothenic acid in adolescence.
01:31:01 Mothers actively transfer pantothenic acid to their fetuses and into their milk at their own expense.
01:33:29 Pharmacokinetics of supplementation
01:42:20 A case for why food is superior to supplements for vitamin B5
01:46:41 Inborn errors of coenzyme A metabolism include pantothenate kinase-associated neurodegeneration (PKAN).
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