048: Pantothenic Acid, Part 1 (What It Is and Why We Need It)

Mastering Nutrition Episode 48

Time Stamps

00:37 Cliff Notes

08:01 Symptoms of experimentally induced pantothenic acid deficiency

09:56 It is thought that pantothenic acid deficiency doesn’t occur naturally.

12:58 Experiments inducing pantothenic acid deficiency

20:05 Signs and symptoms of suboptimal pantothenic acid status

20:53 Is there pantothenic acid toxicity?

24:52 Hypothetical problems of taking high doses of pantothenic acid

25:53 What pantothenic acid is

29:27 Comparisons to niacin and riboflavin

31:13 Roles of coenzyme A

40:02 Roles of 4’-phosphopantetheine

42:11 Burning fat requires 20% more vitamin B5 than burning carbohydrate; and why in the context of severe deficiency of B5 or impairment in the metabolism of B5 a high-fat diet could have devastating consequences.

47:09 The importance of the ratio of acetyl-CoA to free CoA in regulating many metabolic pathways

55:02 There are metabolic disorders, such as fatty acid oxidation disorders, that compromise the pool of coenzyme A.

57:02 Synthesis of coenzyme A

01:00:47 How coenzyme A synthesis is regulated

01:05:38 Degradation of coenzyme A

01:09:44 The physiology of pantothenic acid absorption

01:19:29 A 2015 paper showed that 4’-phosphopantetheine can cross cell membranes via passive diffusion.

01:22:59 The physiology of pantothenic acid transport in the blood

01:26:11 Cellular uptake of pantothenic acid from the blood

01:27:20 Tissue distribution of pantothenic acid

01:30:00 There may be a particularly high need for pantothenic acid in adolescence.

01:31:01 Mothers actively transfer pantothenic acid to their fetuses and into their milk at their own expense.

01:33:29 Pharmacokinetics of supplementation

01:42:20 A case for why food is superior to supplements for vitamin B5

01:46:41 Inborn errors of coenzyme A metabolism include pantothenate kinase-associated neurodegeneration (PKAN).

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