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033: What to Do About MTHFR

Chris Masterjohn Lite Episode 33


Got MTHFR? I got you: here’s what you can do with nutrition to optimize for your genetics.

MTHFR mutations increase your need for choline and glycine. It’s key to get methylfolate in your diet, but high-dose methylfolate supplements are not the solution. You need to boost choline as an alternative supply of methyl groups, and creatine supplementation can help you better conserve your methylfolate by reducing the need to use it. This is important because adequate methylfolate preserves glycine and prevents it from being lost. Too little protein hurts methylation, but too much worsens the loss of glycine, so you need to hit the Goldilocks amount. Finally, you need to get more glycine to make up for whatever you’re losing.

In this episode, I explain how to use food and supplements to make all this work in your favor.

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Chris Masterjohn Lite
“Chris Masterjohn Lite” is a running series of quick tip videos lasting two to five minutes where the name of the game is “Details? Shmetails! Just tell me what works!”
Chris Masterjohn, PhD