How to Find the Root Cause of Autoimmunity?

Question: How do we find the root cause of an autoimmune condition? One example considered where the root cause is energy metabolism.

This is a question asked live during the May 13, 2023 AMA.

Short Answer: Autoimmune conditions are likely driven by deficiencies of vitamins A and D, which contribute to post-infectious autoimmunity by compromising the rhythmic rise and fall of myeloid-derived suppressor cells (MDSCs), and to autoimmunity regardless of infections through impaired suppression of Th17 helper T cells. More broadly, infections and tissue damage are the most likely drivers of autoimmunity onset. However, energy metabolism governs everything through the second law of thermodynamics, which holds that energy must be used to prevent everything from randomly mixing, and this includes randomly mixing the immune defense against pathogens with immune attacks on the host. In this example, we discuss how a respiratory chain disorder would compromise absorption and distribution of zinc and compromise the oxidation of NADH to NAD+, and how both of these would interact with a genetic impairment in acetaldehyde dehydrogenase to prevent the activation of vitamin A to retinoic acid. Autoimmunity thus results as one of many symptoms of vitamin A deficiency driven not by lack of vitamin A, but rather by impaired activation of vitamin A, secondary to impaired energy metabolism. 

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This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Ask Me Anything | May 13, 2023 AMA

Questions on NAC, biofilms, vitamin C and brain fog, energy metabolism driving autoimmune disorders, milk, methylene blue, and more.

• Can NAC hurt your gut health?

• Why Would Vitamin C cause muscle pain, joint pain, and brain fog?

• GLA to lower hydroxyhaemopyrrolin-2-one?

• When would I use the StrateGene and Genova Methylation Panel for nutritional testing?

• Energy metabolism as a root cause of gut issues?

• Nutrition for skin healing?

• Nutrition for hypnic jerks?

• Suggestions for snoring or sleep apnea?

• Nutrition to protect against restaurant meals?

• What is the cause of crusty eyes in the morning?

• What causes brain fog?

• How much oxalate should one eat each day?

• Should I be concerned about low alkaline phosphatase?

• What nutrients give tall children to short parents?

• Energy metabolism impairment mimicking Wilson's disease.

• Can taking digestive enzymes reduce our own production?

• Rapid-fire response to non-winners from the question contest.

Disclaimer

I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

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