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319: What cofactors are needed to synthesize and recycle BH4?

Masterjohn Q&A Files Episode 319
Chris Masterjohn, PhD
Jul 17, 2023
∙ Paid
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Question: What cofactors are needed to synthesize and recycle BH4?

Short Answer: Zinc, magnesium, potassium, and niacin are the cofactors needed for the synthesis and recycling of BH4. Folate and methylation are not involved, though high-dose folate or folic acid could hypothetically hurt BH4 recycling since both are recycled by dihydrofolate reductase (DHFR).

This episode was cut from the original Q&A session that you can find here.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

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Authors
Chris Masterjohn, PhD