13. Pyruvate Dehydrogenase: Why Carbs Leave Your Thiamin Working Overtime

Lesson 13 of Masterclass With Masterjohn: The Antioxidant System

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The pyruvate dehydrogenase complex catalyzes the one decarboxylation step that carbohydrate undergoes to generate acetyl CoA, which accounts for the one carbon dioxide molecule produced in carbohydrate metabolism that is not produced during the metabolism of fat. It also accounts for why burning carbs requires twice as much thiamin as fat. In fact, the …

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