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00:00 The Winner: How useful is hair trace mineral analysis (HTMA) for nutritional testing?

23:12 First Runner-Up: What is the real issue with seed oils?

52:11 Second Runner-Up: Vitamin C: Synthetic Vs. Natural

1:14:27 Butyrate for Hashimoto’s? What else?

1:36:32 What in the comprehensive nutritional screening is helping to interpret lactate/pyruvate and ketone ratios?

1:40:49 Is the solution to a respiratory chain disorder to take Niagen?

1:46:56 If I have high manganese on an HTMA, do I need to detox?

1:48:15 Should CFS patients target reducing their serum BH4?

1:53:36 What to do about low alkaline phosphatase?

1:54:26 If my glucose spikes above 140, should I eat fiber and take ACV before the meal, eat cinnamon with the meal, chew slowly, and move for ten minutes after my meals?

1:56:17 Difficulty getting Quest to do the lactate/pyruvate ratio correctly.

1:57:36 Is 38 milligrams of niacinamide enough to rule out niacin deficiency as a cause of low NAD+?

1:58:12 How does optimizing body composition help optimize energy metabolism? Can impaired energy metabolism make someone fatter?

2:05:32 Is monounsaturated fat the best fat?

2:06:30 Manganese followup.

2:07:13 Do you need to stop taking biotin before a biotin test?

2:08:00 What in "a bunch of supplements" flip the lactate/pyruvate ratio from high to low?

2:10:20 NAD infusions, yay or nay?

2:11:05 Why do I feel better after a warm shower, even better than after sunshine?

2:13:06 Should I cut back on vitamin A if I have toxicity symptoms but cutting back makes me get sick?

2:13:59 Do home blood drop tests have to be pricked at the finger?

2:16:59 Is it true that my boyfriend was just born a night owl?

2:18:21 How much eating out is too much?

2:19:06 When measuring ketones, lactate, and glucose at home to optimize energy metabolism, what time of day should we take the measurements?

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00:00:00 The Winner: Can NAC hurt your gut health?

40:25 First Runner-Up: Why Would Vitamin C cause muscle pain, joint pain, and brain fog?

01:11:29 Second Runner-Up: How do we find the root cause of an autoimmune condition? One example considered.

1:31:21 GLA to lower hydroxyhaemopyrrolin-2-one?

01:41:36 When would I use the StrateGene and Genova Methylation Panel for nutritional testing?

01:49:48 Energy metabolism as a root cause of gut issues?

01:54:34 Nutrition for skin healing?

01:55:53 Nutrition for hypnic jerks?

01:56:35 Suggestions for snoring or sleep apnea?

01:57:12 Nutrition to protect against restaurant meals?

01:58:35 What is the cause of crusty eyes in the morning?

02:02:01 What causes brain fog?

02:03:00 How much oxalate should one eat each day?

02:04:57 Should I be concerned about low alkaline phosphatase?

02:06:11 What nutrients give tall children to short parents?

02:10:21 Energy metabolism impairment mimicking Wilson's disease.

02:12:52 Can taking digestive enzymes reduce our own production?

02:13:52 Rapid-fire response to non-winners from the question contest

• 02:14:15 What do I think of chelation?

• 02:15:02 Is milk good or bad for your bones?

• 02:15:06 How does calcium play a role in acid-base regulation?

• 02:19:48 Why Dante Labs over Nebula Genomics for whole genome sequencing?

• 02:20:15 Dealing with too much omega-3

• 02:22:42 What nutritional tests to get before pregnancy?

• 02:22:58 Nutritional support for repairing myelin?

• 02:25:23 What do I think about food allergy testing?

• 02:26:04 How to improve short-term memory?

• 02:26:49 Why would erectile dysfunction drugs help with heart disease?

• 02:27:25 Should we avoid drinking milk for optimal health?

• 02:27:41 How to interpret carotid intima-media thickness tests?

• 02:29:36 What to do for post-surgery cognitive impairment?

• 02:30:35 What to do about motion sickness?

• 02:34:10 How to manage arginine for pre-workout with HSV-1?

• 02:34:57 Could biotin cause disruption of vitamin A activation?

• 02:36:14 Nutritional support for post-menopausal bone loss?

• 02:38:13 Nutritional preparation for pregnancy?

• 02:38:35 How is psilocybin metabolized?

• 02:38:49 Can lowering animal protein lower ethylmalonic and methylsuccinic acids and improve waking lactate levels?

• 02:42:00 Can beta-alanine help promote new bone growth?

• 02:42:28 Why is my waking glucose consistently 100-108?

• 02:44:39 Are home-cured meat products bad for you?

• 02:45:03 Damaging effects of citrate?

• 02:45:27 What to do for hip pain?

• 02:46:21 What makes infusion of iron the only option?

• 02:46:54 What do I think of methylene blue for general health and metabolic support?

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00:00:00 The Winner: What Causes Hypercholesterolemia and Does It Matter?

00:51:55 The First Runner-Up: Why Should Postprandial Glucose Be Kept Under 140 mg/dL?

01:01:15 The Second Runner-Up: How to Reverse Coronary Calcification?

01:10:28 How to do a comprehensive nutritional screening

01:20:57 How can I protect against oxalates?

01:24:29 How long after eating improperly cooked egg whites should I wait to take biotin?

01:25:09 Is the extrusion process as harmful as some claim?

01:27:23 How long can one fast before micronutrient deficiencies become an issue?

01:32:06 Do B vitamins compete with each other for absorption?

01:33:28 Why is thirst a symptom of diabetes?

01:35:49 Do I agree with Peter Attia that ApoB should be driven as low as pharmacologically possible?

01:43:39 During a fast, does the body break down muscle?

01:45:43 How do you rest and refeed your brain?

01:49:50 Why would someone have high RBC magnesium but low serum magnesium?

01:52:13 GLA deficiency?

01:53:19 Should we eat for our ethnicity?

01:58:49 How convincing are polyphenol studies?

01:59:27 Can coronary calcium be driven by oxalate?

02:00:05 Citrulline for vasodilation

02:00:46 How to reduce catabolism

02:02:55 Rapid-fire run-through of orphaned questions from the submission contest, including a detailed look at Nadia’s thyroid numbers

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Time Stamps

00:00:00 The Winner: Is It Important to Get Vitamin D Sulfate Specifically From the Sun?

00:27:48 The First Runner Up: What cofactors are needed to synthesize and recycle BH4?

00:47:59 The Second Runner Up: How Much Iron Can We Absorb At Once?

01:16:10 What nutrients are important for long-term PPI use?

01:25:09 For how long does transferrin saturation respond to recent iron-rich food?

01:36:11 Muscle spasms: creatine, creatinine, sodium, and potassium.

1:53:21 Hematologists ignore iron saturation.

02:01:14 How to detox arsenic?

02:09:22 Could folic acid supplements impair BH4 recycling?

02:10:04 How to increase butyrate?

02:11:12 More on hematologists and transferrin saturation.

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Time Stamps

0:00:00 The Winner: Can plant foods and their phytochemicals be used to reduce arterial plaque?

0:27:31 First Runner Up: How do I consume omega-3 without hurting my omega-6 status?

0:50:45 Second Runner Up: If I have a hereditary weakness in breaking down branched-chain amino acids, what cofactors do I need to consider, and do I need to restrict my protein when losing weight?

1:11:05 Could carnitine help a fatty acid oxidation disorder?

1:25:55 Should anti-inflammatories be taken away from workouts?

1:34:02 How does vitamin C affect autoimmune disease?

1:38:34 Folate form and purines

1:46:37 Can methylene blue help the respiratory chain?

1:47:43 Best references for omega-3 and inflammation resolution?

1:48:13 Smoothies and blood sugar

1:50:27 Is transdermal magnesium oil effective for osteoarthritis?

1:53:48 Why do K2 and Mg help my nerve pain?

1:58:26 Should I separate my potassium benzoate and vitamin C supplements?

1:59:16 The best and most simple comprehensive micronutrient panel.

1:59:46 How much K2 is needed in pregnancy?

2:03:03 How do I accentuate the fasting-feeding cycle?

2:06:25 Could K2 help with environmental pollution?

2:07:47 Why do shoulders crack when we get older?

2:09:34 Why do I react poorly to anti-inflammatory foods?

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00:00:00 The Winner: Inositol, What Is It Good For?

00:27:51 The First Runner Up: If I am at risk of heart disease, and phosphatidylcholine raises my TMAO, should I stop the supplement?

50:00:00 The Second Runner Up: If undercarboxylated osteocalcin (ucOCN) has health benefits and vitamin K2 decreases it, what does that mean for vitamin K2 supplementation?

01:0:15 Maragen Calcium

01:15:45 Could slow methylation cause high selenium levels?

01:27:46 My current thoughts on cholesterol and heart disease

01:40:57 If I already have oxidative stress, what ducks should I have in a row before supplementing with iron?

01:43:12 Is it safe to take eight milligrams of zinc daily without copper?

01:44:23 What to do about developing sensitivities to an increasingly broad range of foods?

01:49:26 What else to do about hemochromatosis besides phlebotomy?

01:51:01 If gestational diabetes is just a biotin deficiency, why are women who are insulin resistant prior to pregnancy at higher risk for it, including women with PCOS?

01:53:56 What to do about chronically elevated amylase and lipase?

02:00:22 What to do about a non-drinker having very high GGT and occasionally high ALT?

02:04:14 What are the most common vitamin and mineral deficiencies?

02:05:52 What are the best supplements, vitamins, and minerals for OCD and depression?

02:57:59 What is the connection between low pyruvate and high ketones?

02:11:02 Is high LDL a concern if the carotid IMT and coronary calcium scan are clear?

02:15:39 An algorithm to fix twitching

02:22:05 Do I trust food allergy tests?

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Time Stamps

00:00:00 The Contest Winner: Brain Fog Caused by Vitamin D, Vitamin K2, or Calcium

00:24:32 The First Runner Up: How Do I Increase My ATP?

00:49:57 The Second Runner Up: Low Blood Sugar on Vegan Keto

01:05:41 Nutrition for Recovery from Alcoholism

01:14:41 How to decrease MCV after chemo?

01:24:17 What happened to vitamin B4?

01:30:49 Should I eat foods specifically for their antioxidant status?

01:37:52 How do I get my ceruloplasmin up if copper doesn't raise it?

02:02:23 Why would bovine serum immunoglobulins help gut health?

02:03:19 Nicotinamide Riboside and Cancer

02:13:46 If I need lecithin for gut health, should I worry about its omega-6?

02:18:44 What do I think of patented Sucrosomial magnesium and zinc?

02:20:57 Is my problem magnesium transport or magnesium excretion?

02:30:13 What to do about severe osteoarthritis and muscle stiffness?

02:34:43 Should I worry if 5 mg P5P raises my plasma B6 above normal?

02:37:54 Is nascent iodine safe when weaning off of thyroid hormone?

02:39:31 How to avoid false zeros in Cronometer?

02:40:25 What does it mean if I have more energy when taking CoQ10?

02:42:38 If NADPH oxidase is unregulated to fight pathogens, is taking antioxidants good or bad?

02:43:46 What if my needs for vitamin A and zinc are higher than the tolerable upper intake levels?

02:51:37 How accurate are vitamin E tests?

02:53:00 Quick redux on muscle stiffness

02:54:40 How do I handle my first emergence from lockdown if I am worried about being relatively immunosuppressed?

02:59:22 If I supplement with iodine, do I need to supplement with selenium?

03:00:40 Should I worry about the beta-carotene in my multivitamin?

03:01:40 Why do I wake up tense and with a headache to my alarm clock?

03:04:35 Why does starch make me wake up in the middle of the night with increased respiration?

03:06:00 What causes crusty eyes?

03:06:22 Which nutrients need to be spread out across the day?

03:07:56 What are nutritional causes of hypnic jerks?

03:08:37 To replicate Weston Price's reversal of tooth decay, do I need dairy?

03:10:06 Why would I have a bad reaction to milk thistle?

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00:00 The Contest Winner: Statins Vs. Sulfur for Heart Disease

28:27 The First Runner Up: Glutathione Intolerance: Getting to the Bottom of It

56:39 Second Runner Up: Why Plasma Zinc is the Best Marker of Zinc Status

1:19:55 NADH vs NMN vs NR

1:25:33 An unexplained rise in urine ketones

1:27:27 Spreading out calcium across meals

01:28:24 What should we have in our cold season cabinet?

01:31:31 What besides diet could cause my high morning glucose on a CGM?

01:35:28 Will some older people benefit from supplementing carnitine?

01:36:07 What do I think about the CGM fad?

01:39:32 Could my low triglycerides be cholestasis?

01:42:45 Why limit the dose of cod liver oil?

01:43:59 Why do I always feel better when my sulfur problems are worse?

01:46:14 Should I use one lab’s reference range with another lab’s results?

01:49:40 Is it safe to eat roasted potatoes?

01:51:45 How much weight should I give genetic SNPs in my nutrition?

01:55:15 High RBC magnesium but low serum: what could it mean?

01:57:50 Burning in the stomach: what could it be?

01:58:08 Should I treat low plasma amino acids by supplementing them?

01:58:44 Why would MK-4 cause heart palpitations?

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00:00:00 The Contest Winner: Does glucose handling in the brain decline with age? And if so, does this serve as a rationale to supplement with MCT oil to prevent cognitive decline?

37:36 First Runner Up: Does whey protein hurt the kidneys or otherwise hurt our health?

55:28 Second Runner Up: Why would someone not tolerate methyl donors even if they need them?

01:11:51 New cultured oils from Zero Acre Farms

01:18:13 Does DHA raise ApoB?

01:24:06 Why isn't my ferritin as high as diabetics when my transferrin saturation is higher?

01:27:23 Why are vitamins A and E needed alongside D and K?

01:31:49 Sunflower lecithin versus phosphatidylcholine supplements

01:34:28 How do I reduce congestion while consuming dairy?

01:37:53 Could eggs be raising triglycerides by curing fatty liver?

01:41:24 Why would homocysteine ever be high when you can just use it to make glutathione?

01:44:56 Why did my eye start twitching after sweating more than usual this weekend?

01:46:41 Why do I now think A and D should be in roughly 1:1 ratios?

01:50:08 What's the optimal level of secretory IgA?

01:50:48 Would MK-7 be enough to take with D or do I need MK-4?

01:52:42 Why does water make me hungry?

01:54:08 What's the proper ratio of calcium to magnesium, vitamin D, and vitamin K2?

01:54:37 Is it safe to take zinc carnosine long term?

01:55:06 Why did I recommend only using high-dose zinc for COVID protection for one year?

01:56:17 Why did I recommend limiting quercetin phytosome to three months?

01:57:22 Why take MK-4 when it has such a short half-life?

01:58:48 How to make bowel movements more regular?

01:59:23 What are the nutritional causes of nightmares?

2:01:00 Could freeze dried animal beef supplements cause gut infections?

02:02:14 Do I recommend food sensitivity testing?

02:03:44 What are the nutritional causes of restless leg syndrome?

02:04:16 What do I think of drinking deuterium-depleted water for COVID severity?

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00:00 The Contest Winner: Protein and Longevity

32:44 First Runner-Up: How to increase or decrease sex-hormone binding globulin (SHBG)?

46:36 Second Runner-Up: Does which food you eat matter when everything is digested anyway?

01:01:07 How to know if your nitric oxide is dilating your blood vessels properly?

01:08:01 Why is a saline IV hydrating me so much better than drinking salt water?

01:10:55 How big of a problem are transient glucose spikes above 140 mg/dL?

01:16:07 Can I take too much collagen?

01:23:03 What is the maximum dose of cod liver oil safe to use long-term?

01:27:10 How much A is safe to take when I need so much to resolve my symptoms?

01:31:13 Generalizing from cell studies of green tea catechins to cups of green tea per day.

01:37:29 What to do about lumbar discs bulging?

01:43:22 Why would vitamin K2 cause a nosebleed?

01:44:13 How to balance A with D when I react poorly to D and need so much A?

01:50:02 Why would COVID decrease HRV long-term?

01:52:24 How to raise secretory IgA?

01:52:47 What could be causing itchy skin around my liver area?

01:54:42 Rapid-fire answers to pre-submitted questions that didn’t win the contest: alternatives to bone meal powder, herbal tea and nutrient absorption, retinol-binding protein, improving fat digestion, metal provocation tests, fatty liver, high-dose B vitamins, eyebrow thinning, itchy bumps after exercise, brain fog and rifaximin, low cholesterol, tolerating chlorine pools, cycling nutrients, copper toxicity, stopping supplements before blood tests, COVID vaccines causing post-nasal drip, natural vs synthetic vitamins, absorbing iron through baths, elevated EPA and DHA in RBCs, COVID affecting the vagus nerve, supplements for athletic performance, when water doesn’t hydrate, tics and Tourette’s, recalcitrant homocysteine, fraud and corruption in scienctific research.

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Time Stamps

00:01:57 Does folate have any function in the fed state?

00:03:30 How do I know if my digestive enzymes are helping or hurting?

00:11:58 Why does high-dose glycine give me these terrible symptoms?

00:14:55 How to know if my magnesium is messing with my calcium?

00:19:06 Why do I have vitamin A symptoms when my lab tests are normal?

00:33:01 What is my favorite web site for finding enzymatic cofactors?

00:33:47 Potassium citrate vs potassium chloride

00:37:52 Major problems with B vitamin supplements

00:47:52 Is food sensitivity testing useful?

00:48:59 What nutrients might help with dihydropyrimidine dehydrogenase deficiency?

00:51:48 The three phases of fasting: can a little bite of food kick you out?

01:05:42 Does lipoid acid hurt methylation?

01:24:45 What to do about chronic lung congestion?

01:26:39 Why are my urinary B6 markers saying I’m deficient when my plasma levels are high-normal?

01:33:05 Sulfur SIBO that just won’t go away.

01:39:45 The best form of niacin.

01:40:44 Using lactate, pyruvate, and ketone ratios to indicate the NADH/NAD+ ratio.

01:44:59 Can egg white protein hurt biotin status?

01:46:44 Helping bile flow without pharmaceuticals.

01:48:42 Managing pernicious anemia.

01:51:53 Is my high cholesterol really a problem?

01:53:16 Do we really need to meet the RDA for calcium?

01:56:41 Could stretch marks be a sign of copper toxicity?

01:58:40 When iron saturation is driven by low binding capacity.

02:00:54 How do I know if I need methyl-free Bs?

02:02:25 What causes heat intolerance?

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Time Stamps

03:41 What to Do About Persistent SIBO?

20:03 If your CGM conflicts with your HbA1c

27:30 Are there toxicity concerns for vitamin C and copper used for histamine?

33:55 Are there toxicity concerns for intravenous B vitamins?

38:22 Should zinc be taken apart from oral rehydration salts?

39:11 Do reishi, curcumin, or turmeric lower testosterone?

01:06:55 Does baking negate any of the benefits of glycine?

01:07:44 Why would magnesium cause erratic heartbeat, bad dreams, and tinnitus?

01:14:51 How do you know if you have low stomach acid?

01:17:59 Why would my Spectracell show low lipoic acid and CoQ10?

01:23:10 What is a good sweetener to replace granulated sugar?

01:24:19 What to do about chronic tinnitus?

01:25:17 What to do about fat malabsorption when enzymes don’t help?

01:27:17 Is vitamin C a histamine liberator?

01:28:12 Do I need to eat foods with calcium every day?

01:30:24 What do I think about Vibrant nutritional testing?

01:34:41 What bread do I eat?

01:36:57 Is too much milk thistle dangerous?

01:38:50 What are the benefits of raw milk?

01:42:00 How to stop waking up to pee

01:43:05 What to do about glyphosate?

01:47:32 Should you take vitamin D for COVID prevention if you have a history of hypercalcemia?

01:49:56 What to do about extreme CFS, depression, anxiety, and brain fog when nothing seems to work.

01:58:21 Why balance K2 with vitamin E rather than K1?

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Time Stamps

00:01:20 What about NQO1 SNPs?

00:06:24 How to balance vitamins E and K

00:11:38 What’s the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR?

00:19:52 How long does it take to reverse fatty liver?

00:37:50 What prenatal vitamin do I recommend?

00:50:16 Why does my smoothie make my hands cold?

00:52:57 What type of choline to use?

00:56:45 How does iron deficiency anemia lead to tongue swelling?

00:57:42 Why does thiamine help with my elevated heart rate?

01:00:24 Is there an interaction between glycine and aspirin?

01:04:33 What supplements can be used in the fasting state?

01:10:57 How to manage protein intake within a small eating window on an intermittent fasting regimen?

01:18:53 Which cytokines should be measured in blood and which are a waste of money?

01:21:15 Is 300-600 mg of alpha-lipoic acid safe over a long period?

01:25:56 If I was taking 350 mcg of biotin when my blood was tested are the tests invalid?

01:31:45 Does green tea chelate all metals or just iron?

01:35:19 Looking at a study on calcium alpha-ketoglutarate supplementation.

01:39:34 Should I take vitamin D for COVID if I easily get hypercalcemia from it?

01:42:00 What to do about nausea in pregnancy?

01:46:16 Do I recommend broad-spectrum trace mineral supplements?

01:47:11 Brief questions on restless legs, exercise during fasting, puffy eyes, and health effects of spicy foods.

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Show Notes forthcoming.

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Additionally, you may wish to skip over 36:00-36:58 where I am looking for a page in a book and 1:22:52-1:29:00 where it takes me some time to find an image of a chemical structure. 

These will be edited out of the Q&A Files videos that are produced from this AMA.

Here are links to two of the papers covered: 

https://www.cureus.com/articles/36425-nitrous-oxide-induced-posterior-cord-myelopathy-beware-of-the-methyl-folate-trap

https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1016/S0307-4412%2897%2900046-0

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Show Notes forthcoming.

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Show Notes forthcoming.

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